# Research

Explore published research, case studies, and presentations from the Enable Medicine team.

## Publication

### Single-cell spatial multiomics reveals tumor microenvironment vulnerabilities in cancer resistance to immunotherapy
**June 29, 2024**  
**Journal:** [Cell Reports](https://www.cell.com/cell-reports/fulltext/S2211-1247(24)00720-4#%20)  
**Keywords:** Patient response, Single-cell, Spatial multi-omics

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### A single-cell atlas of IL-23 inhibition in cutaneous psoriasis distinguishes clinical response
**January 26, 2024**  
**Journal:** [Science Immunology](https://www.science.org/doi/10.1126/sciimmunol.adi2848)  
**Keywords:** Patient response, Mechanisms of action, Single-cell transcriptomics

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### A machine learning toolkit for automated processing of multiplexed immunofluorescence images
**November 1, 2023**  
**Event:** Society for Immunotherapy of Cancer  
**Keywords:** Image analysis, Tissue detection, Machine learning

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### From images to insights - Deep spatial profiling reveals disease and treatment biomarkers
**November 1, 2023**  
**Event:** Society for Immunotherapy of Cancer  
**Keywords:** Biomarkers, Spatial cellular profiling, Spatial proteomics

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### Integrative Spatial Multi-Omics Analysis of Nsclc Tumor Microenvironment Identifies Key Features Associated With Response to Immune Checkpoint Inhibitor Therapy
**November 1, 2023**  
**Event:** Society for Immunotherapy of Cancer  
**Keywords:** Non-small cell lung cancer (NSCLC), Tumor microenvironment (TME), Spatial-omics

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### An end-to-end Visium spatial transcriptomics computational pipeline for generating low-code interactive reports of spatial insights
**November 1, 2023**  
**Event:** American Association for Cancer Research  
**Keywords:** Spatial transcriptomics, Visium

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### PEPSI: Polarity measurements from spatial proteomics imaging suggest immune cell engagement
**November 1, 2023**  
**Event:** Society for Immunotherapy of Cancer  
**Keywords:** Cell phenotyping, Polarity, Spatial proteomics

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### Characterizing Tissue Structures from Spatial Omics with Spatial Cellular Graph Partition
**November 1, 2023**  
**Event:** Society for Immunotherapy of Cancer  
**Keywords:** Tissue structure segmentation, Diabetic kidney disease (DKD), Spatial-omics

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### emObject: An open-source domain-specific data abstraction for spatial omics
**November 1, 2023**  
**Event:** Society for Immunotherapy of Cancer  
**Keywords:** Data abstraction, Open source, Spatial-omics